In the same manner that pocket calculators made math faster and easier, a new machine-learning tool developed as part of the Department of Energy’s Co-Optimization of Fuels & Engines (Co-Optima) initiative has significantly speeded up calculating the thermodynamics of chemical reactions. The new tool called A machine-Learning derived, Fast, Accurate Bond dissociation Enthalpy Tool (ALFABET) makes it possible for researchers to identify the most promising fuels for lower emissions and greater engine efficiency in seconds rather than days.